While in Paris, Harvard symbologist Robert Langdon is awakened by a phone call in the dead of the night. The elderly curator of the Louvre has been murdered inside the museum, his body and the floor around him covered in baffling symbols. As Langdon and a gifted French cryptologist, Sophie Neveu, sort through the bizarre riddles, they are stunned to discover a trail of clues hidden in the works of Lenoardo Da Vinci - clues visible for all to see and yet ingeniously disguised by the painter.

Even more startling, the late curator was involved in the Priory of Sion - an actual secret society whose memebers included Sir Isaac Newton, Vicotr Hugo, and Da Vinci, among others - and he guared a breathtaking historical secret. Unless Langdon and Neveu can decipher the labyrinthine puzzle - while avoiding the faceless adversary who shadows their every move - the explosive, ancient truth will be lost forever.