When a renowed scientist is found brutally murdered, a Harvard professor, Robert Langdon, is summoned to identify the mysterious symbol seared onto the dead man's chest. His conclusion: it is the work of the Illuminati, a secret brotherhood presumed extinct for nearly four hundred years - now reborn to continue their bitter vendetta agianst their sworn enemy, the Catholic church.

In Rome, the college of cardinals assembles to elect a new pope. Yet somewhere within the walls of the Vatican, an unstoppable bomb of terrifying power relentlessly counts down to oblivion.

While the mintues tick away, Langdon joins forces with Vittoria Vetra, a beautiful and mysterious Italian scienist, to decipher the labyrinthine trail of anicent symbols that snakes across Rome to the long-forgotten Illuminati lair - a secret refuge wherein lies the only hope for the Vatican.

But, with each revelation comes another twist, another turn in the plot, which leaves Langdon and Vetra reeling and at the mercy of a seemingly invincible enemy...